Anal cancer incidence rates increased in antiretroviral era. Author information Copyright and License information Disclaimer. The Hill criteria include defining a temporal relationship between infection and disease, biologic gradient, plausibility, coherence and experimental evidence. Study entry nikki miller anal was used as the time origin and men were at risk up to the date of anal cancer diagnosis or last date of contact or March 30, 2007, whichever came. The group then followed these women for 139-million person-years to examine the incidence of a subsequent primary anal cancer. In addition, cancer risk may not necessarily be related to immunosuppressive treatment, but to the disease .
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